With the arrival of Path of Exile 2 patch 0.4 and The Last Of The Druids league, unique items have received a wave of improvements, rebalancing, and fresh possibilities. Many uniques previously overshadowed by high-tier rares now find a stronger place in both early and endgame. Here we update Path of Exile 2 Unique Tier List for The Last of The Druids based on the new state of uniques in 0.4 update, focusing on which chase unique items are most impactful, flexible, or game-changing in the Fate of Vaal league.

PoE 2 Best Uniques Tier List (0.4)

Patch 0.4 brought a thoughtful approach to unique items, boosting their values and making them more competitive with rare gear. Many uniques are now much more usable in the early and midgame, while some have grown powerful enough to be true endgame options. An overarching theme is the greater roll range on many items, strongly encouraging players to use divine orbs for top results.

There’s a wider range of viable uniques across multiple stages of play. Grand Spectrum jewels, for example, have been buffed and offer substantial resistances or spirit, which can open up affix slots on other gear. The new cap on jewel sockets means players need to be more selective, but the benefits can be immense.

Many iconic items, such as Adorned, Defiance of Destiny, and Cloak of Flame, have moved into new territory with their recent buffs. Some have had their roles refined, while others, like Salin, now offer a chance at completely removing the downside of blocked hits. All of these changes mean that gearing and build planning are more dynamic and creative than ever.

Below is a rundown of the most compelling uniques this league, their roles, and why they’re drawing attention among experienced and theorycrafting players alike.

1. Grand Spectrum Jewels

Grand Spectrum offers a choice between maximum life, spirit, or elemental resistance per spectrum. By using three of the same type, players can achieve huge bonuses. For instance, stacking three Grand Spectrum Sapphires now grants a total of 162% elemental resistance, which can be crucial for freeing up suffixes on rings or making more unique gear viable. The ability to mix and match types adds strategic flexibility, although the reduced number of jewel sockets means each one counts even more.

2. Mahogle

Mahogle has returned to a maximum of 333% effect of socketed soul cores, but comes with a wide roll range. The shield now requires players to be more thoughtful due to the limitation on some augments and soul cores, which now have a maximum of one. While the life core remains stackable, exceptional bases are much rarer than before. Mahogle still provides a strong option for those who can make the most of its unique properties.

3. Adorned

Adorned now reaches up to 150% increased effect of jewel socket passive skills containing corrupted magic jewels, making it a hotly contested prize. The addition of a double corruption altar in the league means each jewel can have a second implicit, leading to highly customizable and powerful passive trees. With enough jewel sockets (up to 12), the min-max potential is enormous. Some builds may even focus on attributes and global defense from jewel implicits, pushing the boundaries of what’s possible.

4. Exhaust’s Blood

Exhaust’s Blood was already decent, but now boasts increased life and a boost from minus 10 to minus 25 for enemies in your presence. It also provides 100 fire resistance, which frees up suffixes for other gear. This item faces competition from other strong chest options, but its combination of offense and defense keeps it in the conversation for many builds.

5. Salin

Salin used to be mostly about lucky block chance, but now features a roll range from 0 to 20. This provides a real opportunity to obtain zero damage from blocked hits, which negates its traditional downside. The shield also received an armor buff, making it an excellent defensive pick if you can secure a high roll.

6. Solos IPS

Solos IPS lets you use the same lineage support gem up to three times in different skills, thanks to a new bonus use. This opens the door for creative setups, such as combining the buffed Zarox Refrain lineage support for multiple spell echoes and increased area of effect. The helmet itself doesn’t provide much else, but for certain multi-skill or echo shenanigans, it might become a build cornerstone.

7. Sinaqua

Sinaqua now immobilizes enemies at half the previous threshold, making freeze, heavy stun, electrocute, and pin much easier to inflict. It also offers 20% more damage to immobilized enemies rather than the old downside, so it’s a competitive option even versus well-rolled rares. Extra armor, evasion, and energy shield increase its appeal for both offense and defense.

8. Defiance of Destiny

Defiance of Destiny has reached a new height as a chase item. Upon taking a hit, you recover 30% of your life before damage is applied, and with corruption and catalysts, this can reach about 40%. This means attacks that don’t exceed 40% of your life are basically negated, and even larger hits are dramatically softened. The amulet slot is more competitive than ever, but for life-based endgame builds, this option is extremely compelling.

9. Choir of the Storm

Choir of the Storm now holds five cooldown charges, allowing for new burst damage combos. While the amulet slot is packed with top-tier contenders, Choir of the Storm has the potential for unique one-off synergies, especially with multiple lightning bolts in a single burst.

10. Wrathpith Globe

Wrathpith Globe still delivers massive global damage and crit, even after being reduced from 5% to 3%. With 5,000 life, it grants 500% increased damage and 150% increased crit, which is still an incredible boost. The new altar mechanic allows for further mod manipulation, and it remains a strong choice for mana-hungry caster builds, even after recent keystone nerfs.

11. Doomfletch

Doomfletch now adds 100% of physical damage as extra of each element, for a total of 300%. While its base damage is low and it lacks attack speed or crit, creative scaling with outside sources can unlock its potential. This bow may serve as an entry point or even a specialized endgame build for the right character.

12. Best Unique Body Armors

• Cloak of Flame and Lightning Coil now offer up to 50% of physical damage taken as elemental (fire or lightning), and with corruption, up to 61%. Recent changes allowing armor to apply to elemental damage mean these armors can provide massive mitigation if you have enough scaling.

• Cotter of Crimson enables life leech to overflow maximum life, letting you reach up to 1.5 times your maximum. Previously it penalized your life, but now it offers a life increase. This makes it a “super comfy” choice for midgame and for builds that can take advantage of leech.

• Cloak of Defiance now gives up to 100 mana regen and 50% of damage taken from mana before life, without the usual recovery penalty. It was already used for Mind Over Matter setups, and this improvement makes it even more appealing.

• Common Calamity boosts herald skill damage by 100%, provides all heralds, and piles on resistances. While it lacks defenses, it can be a strong offensive choice if you can shore up survivability elsewhere.

• Covenant now grants spell damage leech to life and a life remnant skill for overflow, but the life cost for skills may be a downside for many builds.

• Sacro Sanctum saw its energy shield recoup raised to 20%. While niche, it has strong applications for chronomancer builds.

• Harry’s Ira now gives damage as extra and longer freeze duration, refining its focus for specific builds.