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32-Cham 13-Shael 22-Um

Plague [Runewords(Runes)]

32-Cham 13-Shael 22-Um
20% Chance to cast level 12 Lower Resist when struck
25% Chance to cast level 15 Poison Nova on striking
Level 13-17 Cleansing Aura When Equipped (varies)
+1-2 All Skills
+20% Increased Attack Speed
+220-320% Enhanced Damage (varies)
-23% To Enemy Poison Resistance
0.3% (0-29.7) Deadly Strike (Based on Character Level)
+25% Chance of Open Wounds
Freezes Target +3
Plague Runeword

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Price 0.4 USD
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Diablo 2 Plague Wiki & Tips

What is Plague Runeword in Diablo 2 Resurrected?

The Plague Runeword is a powerful runeword in Diablo 2 Resurrected that can be used to create a unique weapon. To create the Plague Runeword, you need to insert the runes Cham and Fal, along with a non-magical or socketed weapon, that has a Clvl requirement of 35 or higher.

When you create the Plague Runeword, the weapon will gain several powerful bonuses, including +150-200% Enhanced Damage, +150-200 to Attack Rating, and +1-2 to all skills. Additionally, the Plague Runeword gives the weapon a chance to cast level 13-15 Poison Nova on striking, which can be very effective against groups of enemies. The Poison Nova effect also causes a cloud of poison to linger on the ground, dealing additional poison damage over time to enemies who remain in the area.

The Plague Runeword is particularly popular for Necromancer characters who use Poison and Bone spells, as it provides a significant boost to these skills and adds additional poison damage to the character's attacks. However, it can also be effective for other character builds that benefit from increased damage and the ability to deal with groups of enemies.

It's worth noting that the Plague Runeword is a ladder-only runeword in Diablo 2 Resurrected, which means that you can only create it in a ladder game or on a ladder character. Additionally, the level requirement to use a weapon with the Plague Runeword is 49, so it's best suited for mid-game characters.

How To Get Plague Runeword in Diablo 2 Resurrected?

In Diablo 2 Resurrected, Plague is a mid-level runeword that can be created by socketing specific runes into a weapon. To create the "Plague" runeword, the following runes must be inserted in order into a three-socketed item:

  • Cham (rune #31)

  • Fal (rune #19)

  • Um (rune #22)

Plague is particularly effective against enemies that are resistant to physical damage, as it deals poison damage that bypasses their defenses. When cast, it creates a cloud of toxic gas that poisons enemies within its radius, dealing damage over time. The skill also has a chance to infect enemies with the Plague ailment, which further damages and weakens them. The cloud created by Plague lasts for a short period of time and can be extended with additional skill points. It can also be used in combination with other Necromancer skills. In addition to its offensive capabilities, Plague can also be used to slow down enemies by reducing their attack speed and movement speed. 

Which Class or Build to Use Plague Runeword in Diablo 2 Resurrected?

Plague is a versatile runeword in Diablo 2 Resurrected that can be used effectively in a variety of different builds. However, it is particularly useful for characters that focus on poison damage and crowd control.

  • One popular build that utilizes Plague is the Poison Necromancer. The Poison Necromancer specializes in dealing poison damage to enemies and using curses to control the battlefield. Plague runeword in D2R can be used to add an additional layer of poison damage and crowd control, making it an excellent choice for this build. When combined with other skills such as Poison Nova, Lower Resist, and Corpse Explosion, the Poison Necromancer can quickly eliminate groups of enemies while keeping them at bay with the Plague cloud.

  • Another build that can benefit from Plague is the Traps Assassin. The Traps Assassin relies on setting traps to deal damage and control the battlefield. D2R Plague can be used to create a cloud of poison that can slow down enemies and provide an additional layer of crowd control. The Traps Assassin can use the Plague cloud to keep enemies at bay while setting traps and dealing damage from a safe distance.

  • Finally, the Diablo 2 Plague runeword can also be useful for a Poison Javelin Amazon. This build utilizes javelins and spears to deal poison damage to enemies from a distance. The Plague cloud can be used to slow down enemies and keep them at bay, making it easier for the Poison Javelin Amazon to deal damage from a safe distance.

What is the Best Base for Plague Runeword in D2R?

The best base for the Plague runeword in Diablo 2 Resurrected depends on the character's playstyle and build. 

  • Plague is a runeword that requires a three-socketed weapon, so the base should have three sockets to be able to create it.

  • Some popular bases for Plague runeword include the Phase Blade, the Superior Dimensional Blade, and the Superior Colossus Blade. The Phase Blade is a fast one-handed sword with low requirements, making it an excellent choice for characters that focus on speed and mobility. The Superior Dimensional Blade is a two-handed sword that can provide a higher damage output, while the Superior Colossus Blade is a slower two-handed sword that can deal massive damage with each hit.

  • Other bases that can be used for Plague runeword include the Cryptic Sword, the War Pike, and the Thresher, among others. Each base has its own advantages and disadvantages, and the best choice will depend on the specific build and playstyle of the character.

It's also important to note that Plague runeword is often used for its poison damage and crowd control effects, rather than its physical damage output. So, it's essential to focus on increasing the skill levels that enhance poison damage, such as Poison Nova or Lower Resist, to maximize the effectiveness of the Plague runeword.

 

Diablo 2 Plague is a Runewords item in the game, and there are a total of 93 D2R Runewords items on sale under this category, with prices ranging from 0.25USD to 64048.51USD.

The Plague Runeword runeword is made by combining the 32-Cham, 13-Shael, 22-Um runes in that order in a weapon that has at least 3 sockets.

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